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KMID : 1151820160100050307
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Journal of the Korean Society of Radiology
2016 Volume.10 No. 5 p.307 ~ p.312
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Usefulness of 18F-Florbetaben in Alzheimer's Disease Diagnosis
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Lee Hyo-Yeong
Im In-Chul
Song Min-Jae
Shin Seong-Gyu
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Abstract
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Alzheimer’s disease is the most common degenerative brain diseases that causes dementia. β-amyloid neuritic plaque density that accumulates in the brain is difficult to perform daily living, such as memory loss, language ability deterioration. It is used to estimate β-amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer’s disease and other causes of cognitive impairment. Using the 18F-Florbetaben with high sensitivity and specificity for the β-amyloid neuritic plaque density to evaluate the usefulness for the early diagnosis of Alzheimer's disease. In 18F-FDG Brain imaging shows no specific findings. And it appeared on the MR-Brain imaging without atrophy of the hippocampus. However, the intake of β-amyloid neuritic plaque density in 18F-Florbetaben informs that it is the progress of Alzheimer's disease. Therefore, 18F-Florobetaben is very useful for early diagnosis of Alzheimer's disease.
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KEYWORD
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Alzheimer's disease, β-amyloid neuritic plaque density, 18F-Florbetaben
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